In 2019 AD, a sudden mysterious flash turns almost all humans into stone, leaving them petrified for 3,700 years. In April 5738, a 15-year-old genius named Senku Ishigami wakes up to find himself in a world devoid of all traces of human civilization. Determined to discover the cause of the event and find a cure, Senku sets up a base camp and studies the petrified humans. His friend Taiju Oki wakes up over the next six months, as he discovers that nitric acid was core to their revival. With this newfound knowledge, they develop a compound that can quickly revive others. They start off by reviving Tsukasa Shishio, a famous high school martial artist, and Yuzuriha Ogawa, their classmate and also Taiju's crush. Together, they aim to rebuild civilization through science.